BIOPROSP_21

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Day 1 - Tuesday 9 March

09:00 - 12:00

Pre-conference activities

1) EU Open Screen workshop
2) Entrepreneurship workshop
3) PhD-workshop

12:00 - 13:00

Lunch

13:00 - 14:00

Opening session

Opening keynote: Using Marine Enzymes to Make Potential Pharmaceuticals

Founding a Spinout Based on Academic Technology

14:00 - 14:15

Coffee break

14:15 - 15:45

Session 1: Accessing biodiversity

The biodiversity of the marine habitat ecosystems: Conservation and sustainable exploitation

Keynote: Biodiscovery using Australian terrestrial and marine biota – the NatureBank approach

The use of Australian-sourced biota for natural product-based agrichemical, nutraceutical, cosmeceutical and drug discovery research has a strategic advantage, since this unique resource has only been superficially explored.

  • NatureBank: A unique biodiscovery platform based on natural product extracts, fractions and compounds derived from Australian plants, fungi and marine invertebrates
  • The identification and biological activity associated with several new natural products that have recently been discovered through a variety of collaborative research programs

Keynote 2: Tara Oceans: Eco-Systems Biology at Planetary Scale

A multidisciplinary consortium, Tara Oceans, was formed around the research schooner Tara, which sampled plankton at more than 210 sites and multiple depth layers in all the major oceanic regions during expeditions from 2009-2013

  • Resources from the project collectively represent the largest DNA sequencing effort for the oceans and analyses that illustrate several aspects of the Tara Oceans’ eco-systems biology approach to address microbial contributions to macro-ecological processes
  • The project provides unique resources for several scientific disciplines that are foundational for mapping ocean biodiversity of a wide range of organisms that are rarely studied together, exploring their interactions, and integrating biology into our physico-chemical understanding of the ocean, as well as for identifying new organisms and genes of biotechnological interest
  • These resources, and the scientific innovations emerging to understand them, are furthermore critical towards developing baseline ecological context and predictive power needed to track the impact of climate change on the oceans

15:45 - 16:00

Coffee break

16:00 - 17:00

Poster speeches

19:30

Opening party

Day 2 - Wednesday 10 March

08:30 - 10:00

Session 2: Tools for marine bioprospecting

Tools from genomics to metabolomics: Cutting edge methods in synthetic biology and accessing compounds from macro and micro algae

Keynote: The informed discovery era, what can we learn from patterns in microbial ‘omics data?

Antarctic actinomycete specialised metabolism

  • Building a platform for linking biosynthetic gene clusters with MS/MS data
  • Patterns of specialised metabolism by biogeography, taxonomy, phylogeny, culture media and growth conditions will be explored
  • Linking the above to bioactivity

10:00 - 10:30

Coffee break

10:30 - 11:30

Poster speeches

11:30 - 12:30

Lunch

12:30 - 13:15

Minisession: Policies

13:15 - 14:45

Session 3: Scale-up and industrialization

Technology scale-up and business innovation from idea to implementation: Regulatory landscape, market opportunities and market authorization

Omega-3 For Prevention and Treatment of Cardiovascular Diseases

  • Review old omega-3 studies
  • Review landmark recent studies and meta-analyses
  • Review recent major meta-analysis
  • Give recommendations for treatment and prevention

14:45 - 15:15

Coffee break

15:15 - 16:15

Poster speeches

18:30

Conference dinner

Day 3 - Thursday 11 March

09:00 - 11:00

Session 4: Success stories

Application of marine research: Marine bioactive compounds, a major opportunity in biotechnological, pharmaceutical or other industries

Marine Microbiome as source of innovative drugs

State of the art in marine biotechnology applied to drug discovery under the experience of PharmaMar, a Spanish company focused in research, development and commercialization of marine derived drugs for the treatment of cancer

  • Early studies of the marine environment focused on natural products from invertebrates and tunicates have led to the isolation of several classes of bioactive natural products mainly small molecules such as polyketides and non-ribosomal peptides. However, there is an emerging suspicion, based on marine sponge/tunicate metagenomics that these compounds originally isolated from metazoan organisms are in fact of bacterial origin. The cases of pederin, ecteinascidins (trabectedin, Yondelis©) or didemnins are some examples of the role of marine microbiome as producers of bioactive metabolites with application in human medicine (oncology)
  • Currently, genomic mining for polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS) improves the probability of success in drug discovery using marine microorganisms, both in isolated genomes and metagenomes

11:00 - 11:15

Coffee break

Biodiscovery of Novel Enzymes at ArcticZymes

ArcticZymes AS is a medium sized enterprise located in Tromsø, Norway, producing novel enzymes for use in molecular biology and diagnostics. ArcticZymes drives its own discovery unit supported by tight partnerships with both academia, private research units and SMEs.

  • In this presentation they will present some of their approaches for the discovery of novel enzymes such as sequence-based exploitation of metagenome data.

12:00

Closing session and lunch